Differentiating features of OCT Angiography in Diabetic Macular Edema
Reza Mirshahi1 , Khalil Ghasemi Falavarjani1 *, Hamid Riazi-Esfahani 2 , Elias Khalili Pour 2 , Kaveh Fadakar2 , Parsa Yarmohamadi3 , Sayyed Amirpooya Alemzadeh 1 , Samira Chaibakhsh 1
- Iran University of Medical Sciences
- Tehran University of Medical Sciences
- Young Researchers and Elite club, Tehran Medical Sciences, Islamic Azad University
Abstract: To evaluate different optical coherence tomography angiography (OCTA) metrics in eyes with diabetic retinopathy with and without diabetic macular edema (DME).
Methods: In this retrospective study, macular OCTA images of eyes with non-proliferative or proliferative diabetic retinopathy were evaluated. Vascular density, vascular complexity and non-perfusion densities were compared between eyes with and without DME.
Results: One-hundred-thirty-eight eyes of 92 diabetic patients including 49 eyes with DME were included. In multivariate analysis, the presence of DME was positively associated with geometric perfusion deficit (GPD) in superficial capillary plexus (SCP), capillary non-perfusion (CNP) of SCP, GPD in deep capillary plexus (DCP), CNP of DCP, and was negatively associated with vascular diameter index (VDI) in SCP and vessel density (VD) of DCP (all P<0.05). In eyes with DME, central foveal thickness was associated with VD ratio (SCP/DCP) (P =0.001) and FAZ area (P=0.001).
Conclusion: In eyes with diabetic retinopathy, the presence of DME was associated with more extensive capillary non-perfusion compared to those with no macular edema.
