Accuracy of Peripapillary Optical Coherence Tomography Angiography in Patients with Acute Non-arteritic Anterior Ischemic Optic Neuropathy
Pasha Anvari1 *, Mahsa Sardarinia 1 , Amin Zand 1 , Kaveh Abri Aghdam 1 , Khalil Ghasemi Falavarjani 1
- Eye Research Center, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Abstract: : To evaluate the accuracy of peripapillary optical coherence tomography angiography (OCTA) segmentation in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) and healthy eyes
Methods: In this retrospective study, 2 en face OCTA images of the optic disc of healthy eyes and eyes with unilateral acute NAION were obtained. The disc boundary and radial peripapillary capillary (RPC) segmentation were generated automatically by the instrument software and then corrected by 2 expert investigators. The frequency of segmentation errors and its impact on vessel density and nerve fiber layer thickness (NFL) measurements was evaluated
Results: : Thirty-eight eyes of 38 subjects (18 in the healthy group and 20 in the acute NAION group) were studied. Misidentified disc border was noted in 5 healthy eyes (27.7 %) and 19 eyes with NAION (95.0 %), (P < 0.001). Segmentation error at RPC level was found in 6 healthy eyes (33.33%) and 19 eyes with NAION (95.0 %) (P < 0.001). The NFL thickness and RPC density did not change statistically significantly after errors corrections in both groups
Conclusion: Misidentification of disc border and segmentation error of the RPC layer are common in OCTA images of the optic disc. Accuracy of OCTA imaging in disc boundary detection and RPC network segmentation is reduced in edematous optic discs following acute NAION.
